Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
نویسندگان
چکیده
منابع مشابه
Neuromelanin MR imaging in Parkinson’s disease
The development and application of neuromelanin sensitive MR imaging has allowed the detection of significant changes in the substantia nigra (SN) of Parkinson’s disease (PD) patients, with high sensitivity and specificity in differentiating PD patients from non-PD aged controls, even in early disease stages, namely at the time of clinical diagnosis. These MR neuromelanin changes in the SN of P...
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In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the early stages, NM synthesis and iron-chelating properties may act as a powerful...
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The expression and significance of tyrosine hydroxylase (TH) in brain tissue of rats with Parkinson's disease (PD) were explored and analyzed. A total of 120 clean-grade and healthy adult Wistar rats weighing 180-240 g were randomly divided equally into four groups according to the random number table method. Rats were sacrificed before and after the model establishment for 3, 6 or 8 weeks. The...
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OBJECTIVE Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD Eleven PD patients performed VF tasks in their STN DBS ON and OFF conditio...
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Research derived from non-invasive brain imaging modalities has been used to explore the spatial and temporal organization of the neural systems supporting human behavior and causing brain disorders. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, and magnetic resonance imaging (MRI). In this talk, we will presen...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-08858-y